P5.15 - Simulation, Manufacturing and Evaluation of Injection Molded Microbioreactors

Event
AMA Conferences 2017
2017-05-30 - 2017-06-01
Nürnberg, Germany
Band
Proceedings Sensor 2017
Chapter
P5 - Gas, Chemo and Biosensors
Author(s)
F. Schütze, N. Matuschek, S. Zinn, A. Böhme, A. Foitzik - University of Applied Sciences Wildau (Germany), L. Santo - University of Rome Tor Vergata (Italy)
Pages
738 - 743
DOI
10.5162/sensor2017/P5.15
ISBN
978-3-9816876-4-4
Price
free

Abstract

Miniaturized flow through devices offer the possibility to mimic the in vivo microenvironment for cultivated cells. In order to guaranty sterility and to eliminate the risk of cross contamination, bioreactors are commonly designed as disposable systems. In order to produce them in large numbers and at low cost, an injection molding process is necessary. Prior to the actual micro injection a simulation software is used to determine the optimal parameter for the injection molding process and machine settings. Hereby, different combinations of processing parameters can be simulated by using a test matrix. Subsequently the optimal setting is used to fabricate the bioreactor. The results are evaluated by comparing the punctual deviations of the actual surface value from the nominal surface value of the CAD-Model.

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