P1BS.4 - A Rhodamine Chemodosimeter Bearing Thiourea Moiety for Mercury(II) and Its Bioimaging Application
- Event
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria - Chapter
- P-1 - Biosensors
- Author(s)
- A. Tantipanjaporn, P. Kongsaeree - Department of Chemistry, Faculty of Science, Mahidol University, Bangkok (Thailand)
- Pages
- 481 - 482
- DOI
- 10.5162/IMCS2018/P1BS.4
- ISBN
- 978-3-9816876-9-9
- Price
- free
Abstract
A selective rhodamine chemodosimeter RTP was developed for Hg2+ detection based on the Hg2+-promoted intramolecular cyclic guanylation of thiourea linked with o-phenylenediamine as a linker. Upon the addition of Hg2+, a colorless solution of RTP turned pink with a maximum absorption band at 555 nm and with a 62-fold fluorescence enhancement at 578 nm (Φ = 0.34). RTP is significantly selective to Hg2+ among other metal ions with a detection limit of 1.6 nM (0.3 ppb). The membrane-permeable RTP probe was successfully demonstrated in Hg2+ monitoring in cultured HeLa cells.