SP 1.1.3 - Tissue corticosteroid rhythms are dysregulated mainly during sleep in primary aldosteronism

Event

EUROSENSORS 2026
2026-09-06 - 2026-09-09
Zurich

Band

Lectures

Chapter

Continuous Health Monitoring in Medicine

Author(s)

M. A. Grytaas, K. Løvås, T. Sjøgren, I. Løvik, A. Heie, G. Å. Ueland - Haukeland University Hospital,Bergen (Norway), T. Upton, G. Russell, S. L. Lightman - University of Bristol,Bristol (United Kingdom), I. Marinelli - University of Exeter,Exeter (United Kingdom), P. Methlie, M. Øksnes, B. E. Oftedal, E. S. Husebye - Haukeland University Hospital,Bergen (Norway) and University of Bergen,Bergen (Norway), D. A. Vassiliadi, D. Margaritopoulos, M. Balomenaki, S. Tsagarakis - Evangelismos General Hospital,Athens (Greece), S. Bensing, I. R. Botusan, K. Berinder, O. Kämpe - Karolinska University Hospital,Stockholm (Sweden) and Karolinska Institutet,Stockholm (Sweden), K. Simunkova - University of Bergen,Bergen (Norway), B. Lombard - University of Birmingham,Birmingham (United Kingdom), E. Zavala - University of Birmingham,Birmingham (United Kingdom) and University of Manchester,Manchester (United Kingdom)

Pages

280 - 280

DOI

10.5162/eurosensors2026/SP1.1.3

ISBN

978-3-910600-12-6

Price

free

Abstract

Ultradian platform enables ambulatory, tissue-level profiling of steroid hormones, every 20 minutes over 24 hours. We applied this wearable microdialysis platform in patients with primary adrenal insufficiency receiving different glucocorticoid replacement regimens. Compared with healthy reference profiles, patients spent less time within the physiological cortisol range.These findings reveal dynamic treatment mismatches that conventional sparse sampling cannot capture. Ultradian platform provides a route toward precision endocrine monitoring and individualized glucocorticoid replacement.