E6.2 - Development of an Electronic Nose System to Diagnose Heart Failure from Human Skin Odor
- Event
- AMA Conferences 2013
2013-05-14 - 2013-05-16
Nürnberg - Band
- Proceedings SENSOR 2013
- Chapter
- E6 - Gas Sensors I
- Author(s)
- A. Voss, K. Witt, C. Fischer, S. Reulecke, W. Poitz - Ernst-Abbe-Fachhochschule Jena (Germany), V. Kechagias, R. Surber, H. Figulla - Universitätsklinikum Jena (Germany)
- Pages
- 648 - 649
- DOI
- 10.5162/sensor2013/E6.2
- ISBN
- 978-3-9813484-3-9
- Price
- free
Abstract
The human body odor contains different volatile organic compounds which can be used as biomarkers for various diseases. The early detection of heart failure (HF) through periodical screening provides an early diagnosis and treatment application. Therefore, we have developed a completely new non-invasive method to identify HF applying an "electronic nose" (e-nose) which provides a "smelling" of the disease based on the analysis of sweat volatile gases from the skin surface. The sensor element of the e-nose was directly applied on the skin surface (crook of the arm). 27 patients with decompensated HF (DHF), 25 patients with compensated HF (CHF, mean age 70.72 ± 12.02) and 28 controls (CON) were enrolled. Principal component analysis was performed in combination with discriminant function analysis to discriminate between the patient groups. DHF were separated from CHF with an accuracy of 87% whereas the CON were successfully discriminated from CHF in 85%. The results of this pilot study suggest that an e-nose could be successfully applied for a
noninvasive diagnosis and monitoring of HF analyzing the patients’ body odor from skin surface.