A3.1 - Molecularly Imprinted Polymers as Selective Receptors for Sensing Nanosized Species
- AMA Conferences 2017
2017-05-30 - 2017-06-01
- Proceedings Sensor 2017
- A3 - Biosensors II
- S. Chunta, C. Jungmann, L. Schranzhofer, P. Lieberzeit - University of Vienna (Austria), R. Suedee - Prince of Songkla University, Hatyai (Thailand)
- 66 - 68
Molecular imprinting into highly cross-linked polymers has attracted substantial interest for a wide range of analytes. Herein, we present two application examples of molecularly imprinted polymers (MIP) as artificial receptors for chemosensors: both analytes, namely high densitiy lipoprotein (HDL) and engineered gold nanoparticles, respectively, share their dimensions in the range of a few ten nm. Utilizing the resulting surface MIP as artificial receptors on quartz crystal microbalance (QCM) sensors leads to appreciable results. In both cases, MIP yield much higher sensor responses (up to an order of magnitude higher), than their non-imprinted counterparts. MIP sensors reveal dynamic sensor signals, for HDL in the physiologically interesting range. The two examples hence show the potential of molecular imprinting for designing receptor layers targeting analytes in the nanometer range.