DH2.3 - Virtual Electronic Nose for Simultaneous Detection of Hydrogen and Methane in Breath on the Diagnosis of Gastrointestinal Diseases

17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria
Sensors for Diagnostics and Health Care 2
F. Gao, X. Zhang, M. Wang, J. Zhang, H. Wan, P. Wang - Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou (China)
149 - 150


Breath test is a prevalent detection method for gastrointestinal function, which is widely used on the diagnosis of carbohydrate malabsorption, small intestinal bacterial overgrowth (SIBO) and other gastrointestinal diseases. This study proposed a non- invasive method utilizing a virtual electronic nose to simultaneously detect hydrogen and methane concentration in breath which were corrected by the carbon dioxide to eliminate the effect on the alveolar gas. The detection range of the virtual electronic nose system was 1-200 ppm, and the resolution was 1 ppm, and the precision was less than 10%, and the single detection time was significantly shortened to 90s, as well as the size reduced to (40cm×30cm×15cm). Forty-seven cases of healthy people and patients were collected, and the types of concentration curve were judged accurately, and the SIBO diagnostic model was established. This method has the advantages of high specificity, non-invasive and simplicity of operation, so that can be used for the detection of increasing volume of clinical and domestic patients.