EC2.3 - Incorporation of Sugar into Conducting Polymer Enables Specific Biosensing of Human Influenza Virus
- Event
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria - Chapter
- Electrochemical Sensors 2
- Author(s)
- T. Goda, W. Hai, H. Takeuchi, S. Yamaoka, Y. Horiguchi, A. Matsumoto, Y. Miyahara - Tokyo Medical and Dental University (TMDU), Tokyo (Japan)
- Pages
- 221 - 222
- DOI
- 10.5162/IMCS2018/EC2.3
- ISBN
- 978-3-9816876-9-9
- Price
- free
Abstract
Early detection of influenza virus is key to the prevention of pandemics, which cause up to 500-thousands deaths worldwide each year. Current diagnostic methods are limited by time, sensitivity, cost, or ease of use. We exploited the ability of conjugated polymers to chemically receive a “graft” of 2,6-sialyllactose, a trisaccharide that could recognize and specifically bind to human influenza virus, into their building blocks. Conducting polymers conduct electricity, and their advantages of low toxicity and flexibility make them suitable for use in biological systems as biosensors. This binding was detected by measuring small electrical changes of the functionalized poly(ethylenedioxythiophene) (PEDOT) either by potentiometry or amperometry, enabling the virus to be identified as low as 0.01 hemagglutinating unit (HAU). The potential mass productivity of this approach could allow on-site viral detection, which would be particularly beneficial in remote areas.