T6.3.2 - DNA-scaffold biosensors for real-time pH tracking in dynamic environments
- Event
- EUROSENSORS XXXVII
2025-09-07 - 2025-09-10
Wroclaw - Band
- Lectures
- Chapter
- T6.3 - Biochemical and Environmental Sensors 2
- Author(s)
- G. Antonelli, A. Mencattini, G. Curci, J. Filippi, A. Riccardi, P. Casti, E. Debbi, M. D’Orazio, E. Martinelli - Department of Electronic Engineering, University of Rome Tor Vergata, Rome (Italy), A. Chamorro-Garcia, A. Idili - Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome (Italy), P. Spitalieri, F. Sangiuolo - Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome (Italy)
- Pages
- 160 - 161
- DOI
- 10.5162/EUROSENSORS2025/T6.3.2
- ISBN
- 978-3-910600-07-2
- Price
- free
Abstract
Lab-on-chips have transformed the approach to studying biological models for drug discovery. However, some information could be misinterpreted without knowing the chemical information near the biological entity. In this work, we exploited DNA scaffolds to realise fluorescent hydrogel pH microsensors that can be easily integrated into lab-on-chips. A machine learning model was trained to read the biosensors’ response and predict pH in a dynamic microfluidic environment. The proposed system is highly biocom-patible and can be used in many biological applications, such as monitoring organoids’ metabolism.