EC1.2 - Development of real-time monitoring of alkaline phosphatase (ALP) biomarker released from cells based on microelectrode arrays for clinical analysis
- Event
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria - Chapter
- Electrochemical Sensors 1
- Author(s)
- T. Balbaied, W. Messian, E. Moore - University College Cork, Tyndall National Institution, Cork, Mardyke St, (Ireland)
- Pages
- 188 - 189
- DOI
- 10.5162/IMCS2018/EC1.2
- ISBN
- 978-3-9816876-9-9
- Price
- free
Abstract
Alkaline phosphatase (ALP) biomarker is a membrane-bound enzyme widely distributed in the tissues of living organism. Abnormal level of ALP indicates diseases such as liver dysfunctions, bone disorders, ulcerative colitis, acute kidney injury and can diagnose cancer at early stage. There is thus a demand for a reliable technique to accelerate the sensing of ALP in point-of-care applications. Such methods although sensitive are costly process, and based on optical detections, which hard to be miniaturized. This work presented shows a method that integrates cell culture and electrochemical techniques to develop real-time detection of monitoring ALP released from cells.