NA.1 - Graphene-Based Biosensors for Diagnostics
- Event
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria - Chapter
- Nanoarchitectures in Sensing
- Author(s)
- A. Johnson - Department of Physics and Astronomy, University of Pennsylvania, Philadelphia (USA)
- Pages
- 280 - 281
- DOI
- 10.5162/IMCS2018/NA.1
- ISBN
- 978-3-9816876-9-9
- Price
- free
Abstract
We review recent results from our group in graphene-enabled biosensors for diagnostics and other applications. Scalable manufacturing approaches for graphene field effect transistors (GFETs) and graphene microelectrodes have been realized. GFET-based nucleic acid detectors based on complementary probes have a limit of detection of order 1 nM for 20mer and 1 aM for 80mer targets. The system is compatible with DNA engineering strategies including the use of hairpin probes and hybridization chain reaction as well as DNA aptamers for detection of small molecule targets. Biofunctionalized graphene microelectrodes are single-terminal devices that have been used as biosensors with pM sensitivity and specificity consistent with the chemical recognition element.