B1-c3 - UTMD-Mediated Nano-Stem Cells for the Treatment of Ischemic Stroke
- Event
- 2025 ICU PADERBORN - 9th International Congress on Ultrasonics
2025-09-21 - 2025-09-25
Paderborn - Band
- Lectures
- Chapter
- B1-b - Biomedical Ultrasound for Therapy and Diagnosis
- Author(s)
- M. Li, L. Du, F. Li - Shanghai Jiao Tong University School of Medicine, Shanghai (China)
- Pages
- 150 - 152
- DOI
- 10.5162/Ultrasonic2025/B1-c3
- ISBN
- 978-3-910600-08-9
- Price
- free
Abstract
Ischemic stroke, a leading cause of global disability and death, affects about 15 million annually. Current therapies face limitations from narrow treatment windows and the blood-brain barrier (BBB), which restricts drug delivery. Nanotechnology offers promising solutions: copper-selenium nanoparticles (Cu2-xSe) combine biocompatibility with antioxidant/antiinflammatory effects, scavenging ROS and modulating ferroptosis. Selenium upregulates GPX4 via TFAP2c/Sp1, inhibiting lipid peroxidation. Similar Cu-based nanozymes have shown anti-inflammatory effects in osteoarthritis by modulating macrophage polarization. Stem cell therapy, particularly BMSCs, promotes neurorepair through differentiation and neurotrophic factor secretion. Our innovation combines UTMD technology - which transiently opens the BBB via microbubble cavitation - with engineered Cu2-xSe@BMSCs. This multimodal strategy simultaneously addresses BBB penetration, oxidative stress, inflammation, apoptosis, and neural regeneration.