B2.2 - Multi-Way Biosensors: Development and Commercialization

SENSOR+TEST Conferences 2009
2009-05-26 - 2009-05-28
Congress Center Nürnberg
Proceedings SENSOR 2009, Volume I
B2 - Medical Application II
D. Zahn, J. Szeponik, A. Gandhi - BST Bio Sensor Technology GmbH, Berlin, Germany
169 - 174


The main milestones in biosensor history till 2000 include, e.g.,
• 1962 – 1st Description of an (amperometric glucose) biosensor
• 1969 – 1st Potentiometric biosensor (for urea)
• 1972/75 – 1st Commercial biosensor (YSI, Ohio, USA)
• 1982/1986 – 1st Commercial biosensor in Europa ( CSE Berlin, Germany / PGW Medingen /
ENH Hamburg, Germany)
• 1987 – 1st Commercial biosensor for Blood Glucose Home Monitoring (MediSense/ExacTec)
• 1990 – Launch of SPR based BIAcore (Pharmacia/Sweden)
In 1997 the IUPAC committee did agree on the following definition of a biosensor:
An electrochemical biosensor is a self-contained integrated device, which is capable of providing specific quantitative or semi-quantitative analytical information using a biological recognition element (biochemical receptor), which is retained in direct spatial contact with an electrochemical transduction element. Because of their ability to be repeatedly calibrated, we recommend that a biosensor should be clearly distinguished from a bioanalytical system, which requires additional processing steps, such as reagent addition. A device that is both disposable after one measurement, i.e., single use, and unable to monitor the analyte concentration continuously or after rapid and reproducible regeneration should be designated
as a single-use biosensor.
From the beginning in 1975 the Berlin biosensor group did deal NOT with “single-use biosensors”, but with “multi-use” or “multi-way biosensors”. In comparison to single-use biosensors multi-way biosensors can be used for more than one analysis, at least twice. The advantages of multi – way biosensors in principle are i) the possibility of calibration causing a high
analytical performance and ii) the possibility to achieve cost-effective analytical tools.