8.1.2 Recording of living cell membrane depolarisation with AlGaN/GaN sensor
- 14th International Meeting on Chemical Sensors - IMCS 2012
2012-05-20 - 2012-05-23
- 8.1 Chemical Sensors based on III-V Semiconductors
- A. Podolska, G. Parish, B. Nener - School of Electrical, Electronic and Computer Engineering, The University of Western Australia (Australia), R. Seeber, K. Pfleger - Laboratory for Molecular Endocrinology - GPCRs, Western Australian Institute for Medical Research (WAIMR), and Centre for Medical Research, The University of Western Australia (Australia), U. Mishra - Department of Electrical and Computer Engineering, University of California (USA)
- 665 - 666
This work reports on AlGaN/GaN-based sensor development and application to biological sensing. Living cells were seeded on the sensitive region of encapsulated devices for 30 minutes before membrane depolarisation with KCl. To confirm cell activity KCl was also added to devices in physiological salt solution with no cells. The resulting responses were recorded in both cases and demonstrated significant differences in profile and amplitude. Since the AlGaN/GaN structure itself is ion-sensitive, a chemical signal is expected even in the absence of cells. The depolarisation signal observed for the devices with cells is thus expected to incorporate this chemical response.