2025 SMSI Bannerklein

A16 - Photolithographic local surface modification of integrated evanescent wave based biosensors

Event
11. Dresdner Sensor-Symposium 2013
2013-12-09 - 2013-12-11
Dreikönigskirche - Haus der Kirche Dresden
Chapter
1. Biosensorik und Point of Care
Author(s)
E. Melnik, P. Müllner, R. Hainberger - AIT Austrian Institute of Technology GmbH, Wien/A, M. Lämmerhofer - Institute of Pharmaceutical Sciences, Tübingen/D
Pages
193 - 197
DOI
10.5162/11dss2013/A16
ISBN
978-3-9813484-5-3
Price
free

Abstract

Photolithographic local surface modification was performed on mercaptopropyl trimethoxy silane modified Mach-Zehnder interferomteric sensors, by using thiol-ene coupling reaction for the selective blocking of non-sensing and reference areas. The reactive thiol groups remaining after the photolithographic step were biotinylated to enable the measurement of chromeon 642-streptavidin. The surface characterization was performed with fluorescence imagining and chromeon 642-streptavidin measurement on Mach-Zehnder interferomteric sensors.

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