A16 - Photolithographic local surface modification of integrated evanescent wave based biosensors
- Event
- 11. Dresdner Sensor-Symposium 2013
2013-12-09 - 2013-12-11
Dreikönigskirche - Haus der Kirche Dresden - Chapter
- 1. Biosensorik und Point of Care
- Author(s)
- E. Melnik, P. Müllner, R. Hainberger - AIT Austrian Institute of Technology GmbH, Wien/A, M. Lämmerhofer - Institute of Pharmaceutical Sciences, Tübingen/D
- Pages
- 193 - 197
- DOI
- 10.5162/11dss2013/A16
- ISBN
- 978-3-9813484-5-3
- Price
- free
Abstract
Photolithographic local surface modification was performed on mercaptopropyl trimethoxy silane modified Mach-Zehnder interferomteric sensors, by using thiol-ene coupling reaction for the selective blocking of non-sensing and reference areas. The reactive thiol groups remaining after the photolithographic step were biotinylated to enable the measurement of chromeon 642-streptavidin. The surface characterization was performed with fluorescence imagining and chromeon 642-streptavidin measurement on Mach-Zehnder interferomteric sensors.