BS4.2 - Label-free detection of nucleic acids and proteins using impedance spectroscopy and surface plasmon resonance
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
- Biosensors 4 - Novel Transducers
- F. Lisdat, M. Riedel, F. Heinrich - Biosystems Technology, Institute of Applied Life Sciences, Technical University Wildau, Wildau (Germany)
- 180 - 181
Label-free technologies have gained increasing interest in sensing. The presentation focuses on the use of impedance measurements for the analytical detection of nucleic acids including abasic DNA and DNA-binding proteins. It will show how pitfalls can be avoided by elimination of drift phenomena. Furthermore, it will illustrate the usefulness of surface plasmon resonance in the detection of conformational changes and the discrimination of two rather similar proteins.