BS4.3 - Lethal Disease Discrimination Using Silicon Nanowire-Based Field-Effect Transistors
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
- Biosensors 4 - Novel Transducers
- B. Ibarlucea, L. Baraban, G. Cuniberti - Institute for Materials Science and Max Bergman Center of Biomaterials, Center for advancing electronics Dresden (cfaed), Technical University of Dresden, Dresden (Germany), T. Rim - Department of Creative IT Engineering, Pohang University of Science and Technology, Pohang (South Korea)
- 182 - 183
We present a sensor chip with an array of silicon nanowire-based field-effect transistors, biofunctionalized with different antibodies for multiplexed biosensing. The fabrication is done following a reproducible top-down process, defining honeycomb-shaped nanowires for an enhanced sensing area and an improved mechanical stability. A covalent immobilization of the antibodies provides a strong stability of the bioreceptors. The demonstration is done by discriminating Ebola virus VP40 matrix protein from Cholera toxin B subunit and Staphylococcal enterotoxin B. The array shows a high sensitivity by responding to femtomolar concentrations, and allowing to distinguish a lethal disease from others showing similar initial symptoms. Such device would allow performing early diagnosis to prevent a fast spreading of the diseases.