P1AP.11 - Online Copper Monitoring for Pharmaceutical Processes
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
- P-1 - Applications of Chemical Sensors
- J. Jo - Merck Research Laboratories, Rahwa (USA), J. Jungr - Penn State University, Dunmore (USA)
- 456 - 457
A copper-mediated cyclization which converts ortho-azo anilines to benzotriazoles was utilized to detect residual copper(II) ion in pharmaceutical compounds such as active pharmaceutical ingredient (API) and process intermediates. Adjusting electronic property by both the number of electron donating group (EDG) and the position of EDG remarkably promoted the reactivity toward copper (40-times faster) than the benchmark compound. The sensitivity was also markedly increased so the limit of detection is 20 times lower than the benchmark compound. Especially the rapid responses in both color and fluorescence enable the copper probe to be applied as a real-time monitoring tool which was incorporated within high performance liquid chromatography (HPLC). Detail of comparative kinetic studies, structure-reactivity relationships, and its application toward industrial processes will be discussed in the presentation.