P2BM.2 - Proto-MIP – A novel route for MIP fabrication
- Event
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria - Chapter
- P-2 - Biomimetic Sensors
- Author(s)
- S. Haas, L. Schranzhofer - Profactor GmbH, Steyr-Gleink (Austria)
- Pages
- 688 - 689
- DOI
- 10.5162/IMCS2018/P2BM.2
- ISBN
- 978-3-9816876-9-9
- Price
- free
Abstract
Molecular Imprinting is a method to synthesize materials with biomimetic properties that can be used in sensor systems or assays replacing their biological equivalents like antibodies or cells. Due to the self assembly step and polymerization chemistry, MIPs bear the drawback of low fabrication reproducibility of 20 – 50%, a reason for MIPs being less used in applications. Proto-MIP is aimed to a spatially separated self-assembly process during generation of an imprinted layer of anchor groups around an immobilized template, like bacteria or molecules. This is followed by merging this anchor group layer with an UV-curable resin to generate a full MIP layer within seconds. Yielding an imprinted layer resembling shape, size and complementary chemical information of the template, which is exhibiting an affinity of high sensitivity and specificity towards the respective antigen or analyte. The adaption of MIP fabrication to UV-NIL processes enables improved batch fabrication and reduction of fabrication time and costs.