P2BM.6 - Tailoring Molecular Imprinted Polymers as Biomimetic Recognition Coatings for Anti-Diabetic Drugs
- Event
- 17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria - Chapter
- P-2 - Biomimetic Sensors
- Author(s)
- A. Mujahid, I. Haq, T. Hussain - Institute of Chemistry, University of the Punjab, Lahore (Pakistan), S. Bajwa - National Institute of Biotechnology and Genetic Engineering, Faisalabad (Pakistan), A. Afzal - Department of Chemistry, College of Science, University of Hafr Al Batin, Hafr Al Batin (Saudi Arabia)
- Pages
- 696 - 697
- DOI
- 10.5162/IMCS2018/P2BM.6
- ISBN
- 978-3-9816876-9-9
- Price
- free
Abstract
Molecular recognition of pharmaceutical molecules in complex mixtures is a subject of significant interest both for clinical analysis and routine quality control assays in pharma industries. The ever increasing use of anti-diabetic drugs e.g. sitagliptin and metformin also demand their selective extraction and quantitative determination. In present study, we tailored molecular imprinted polymer matrix as highly responsive chemical sensor coatings for molecular recognition of above mentioned anti-diabetic drugs. Molecular imprinted coatings were synthesized as poly(methacrylic acid) crosslinked with ethyleneglycol dimethacrylate following free radical initiated polymerization. The imprinted polymer was processed in gel form and integrated with interdigital capacitors (IDCs) as thin layers by spin coating. The prime advantages of using IDCs are their low fabrication cost, rapid response time and ruggedness. The synthesized imprinted sensor layers have shown appreciable response for target analytes comparing to non-imprinted/control material. Therefore, the developed sensor coatings can be suitably used for specific drug analysis and related bioassay of anti-diabetic drugs.