TP63 - Direct-printed, solid-contact pH sensor for clinical applications: Challenges of non-specific adsorption
- Event
- EUROSENSORS XXXVII
2025-09-07 - 2025-09-10
Wroclaw - Band
- Poster II
- Chapter
- Sensors for Medicine and Life-Sciences
- Author(s)
- M. Urbanowicz, A. Paziewska-Nowak, K. Bobrowska, A. Sołdatowska, M. Dawgul, D. G. Pijanowska - Polish Academy of Sciences, Warsaw (Poland), M. Ekman - Medical University of Gdańsk, Gdańsk (Poland)
- Pages
- 480 - 481
- DOI
- 10.5162/EUROSENSORS2025/TP63
- ISBN
- 978-3-910600-07-2
- Price
- free
Abstract
We present a solid-contact pH sensor based on an hydrogen ion-selective membrane (ISM).The sensor substrate was fabricated using direct printing technology. A conducting polymer, polyazu-lene (pAz), was applied as an ion-to-electron transducer layer. Metrological characterization demon-strated that the sensor operates over a wide range of hydrogen ion concentrations, exhibiting a fast Nernstian response. Additionally, surface plasmon resonance (SPR) was employed to study the non-specific adsorption of organic molecules on the ISM-coated gold chip. Studies have shown that for pro-teins, the non-specific adsorption to ISM is dependent on the isoelectric point. In the case of drugs, it was shown that the non-specific adsorption of ibuprofen is much higher than that of acetaminophen.