TP68 - Microphysiological analytical chip with non-invasive Raman microspectroscopy analysis of epithelial permeability and inflammatory biomarkers
- Event
- EUROSENSORS XXXVII
2025-09-07 - 2025-09-10
Wroclaw - Band
- Poster II
- Chapter
- Sensors for Medicine and Life-Sciences
- Author(s)
- A. Calogiuri, D. Bellisario, E. Sciurti, L. Blasi, V. Esposito, F. Casino, P. Siciliano, L. Francioso - Institute for Microelectronics and Microsystems IMM-CNR, Lecce (Italy)
- Pages
- 490 - 491
- DOI
- 10.5162/EUROSENSORS2025/TP68
- ISBN
- 978-3-910600-07-2
- Price
- free
Abstract
The presented work reports the non-invasive detection of multiple biomarkers in a custom microphysio-logical chip, designed for co-culture tissues and organ-on-chip investigations. The proposed SERS-on-chip detection system is optimized for the specific detection of two colorectal cancer biomarkers at phys-iological concentrations, the Oncostatin M and TNF-α. Under optimized pH conditions, tuned on-board,the ML algorithm in F₁₂K medium achieved 99 % accuracy for Oncostatin M detection and 92 % accu-racy vs TNF-α detection.