Tu-MLO-06 - A Microfluidic Device Integrating Electrical Impedance Spectroscopy Enables Label-Free Monitoring of C. elegans in Egg-Laying

Event

EUROSENSORS 2026
2026-09-06 - 2026-09-09
Zurich

Band

Poster

Chapter

Microfluidic Devices, Lab on a Chip, µTAS, Organ on Chip Systems

Author(s)

S. Yu, Y. Geng, J. Fan, H. Lu, Z. Zhu - Southeast University,Wuxi (China)

Pages

509 - 510

DOI

10.5162/eurosensors2026/Tu-MLO-06

ISBN

978-3-910600-12-6

Price

free

Abstract

Accurate characterization of reproductive phenotypes in Caenorhabditis elegans ( C. elegans ) is essential for investigating underlying physiological processes and hereditary mechanisms. However, monitoring of the egg-laying process, one of the central reproductive behaviors in C. elegans , has relied on counting expelled embryos, while overlooking organ-level dynamics within the animal, particularly those of the uterus. Here, we present a microfluidic device integrating a microelectrode array to perform electrical impedance spectroscopy measurements of C. elegans uterus. Both simulation and experimental results demonstrate that impedance signals at 40 MHz are correlated with the uterine state changes during egg-laying.