Tu-SMD-07 - Sugar-Based Electrochemical Biosensors for Quantification of a Secreted Protein in Human Fluids

Event

EUROSENSORS 2026
2026-09-06 - 2026-09-09
Zurich

Band

Poster

Chapter

Sensing For Medical Diagnostics And Monitoring

Author(s)

J. Guo, L. Salmon, H. Korri-Youssoufi - Université Paris-Saclay,Orsay (France), H. Le Stunff, Y. Benomar - Université Paris-Saclay,Gif-sur-Yvette (France)

Pages

616 - 617

DOI

10.5162/eurosensors2026/Tu-SMD-07

ISBN

978-3-910600-12-6

Price

free

Abstract

Obesity is a major risk factor for Type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), two highly prevalent metabolic disorders with substantial clinical burden. Phosphoglucose isomerase (PGI), classically recognized as a key glycolytic enzyme, has recently emerged as a candidate biomarker for metabolic disease because of its extracellular function as a cytokine. In this study, we report the development of electrochemical biosensors for the sensitive detection of PGI in plasma and evaluate their performance in high-fat diet-induced mouse models of obesity. We show that these biosensors reliably detect circulating PGI and enable monitoring of its levels in the context of diet-induced obesity. Together, these findings identify circulating PGI as a potential early biomarker of obesity-associated metabolic disorders and highlight electrochemical biosensing as a promising non-invasive approach for the early diagnosis and monitoring of obesity-driven metabolic disease progression.