P1.03 - Continuous In-Line Monitoring of Electrolyte and Urea Concentrations in Extracorporeal Circuits

14. Dresdner Sensor-Symposium 2019
2019-12-02 - 2019-12-04
P1. Anwendungen
M. Berger, S. Zimmermann - Leibniz University Hannover, Hannover/D, F. Sellering, H. Röhrich, T. Perl - University Medical Center Göttingen, Göttingen/D, H. Mansour - Barkey GmbH & Co. KG, Leopoldshöhe/D, D. Baasner - InnoME GmbH, Espelkamp/D
113 - 118


The individualization of dialysis treatment is receiving more and more attention in research, because it can be beneficial particularly for critical ill patients in intensive care units (ICU) with acute kidney injury (AKI) [1–6].
AKI is understood as the rapid loss of the kidney’s function. It is typically diagnosed by the accumulation of end products of the nitrogen metabolism such as urea nitrogen and creatinine in combination with reduced urine output [7]. AKI is often developed by critically ill patients with e.g. multi-organ failure or sepsis in ICU [8–10]. Such patients show a mortality rate of more than 50 % [11]. The treatment of critical ill patients with AKI is usually the continuous renal replacement therapy (CRRT) [11–14]. The major difference between CRRT and the regular intermitted dialysis, applied to chronic kidney diseases, is the duration of treatment as well as the rate at which water and wastes are removed from the extracorporeal circuit via diffusion across the semipermeable membrane of the dialyzer [12]. While intermitted dialysis aims at a maximum clearance of waste products and normalization of electrolytes at a treatment duration of 3-4 hours, CRRT focuses on a significantly slower normalization of blood parameters over a treatment duration of several days, resulting in a benefit for critical ill patients, as a rapid change of osmotic substances can lead to different complications [6,12,15].