Mo-BBS-06 - Computational Design of Peptide Recognition Elements for Rapid Detection of Neurotoxin Exposure

Event

EUROSENSORS 2026
2026-09-06 - 2026-09-09
Zurich

Band

Poster

Chapter

Biosensors/-electronics And Biomimetic Sensors

Author(s)

M. Al-gafari, A. Tayabali - Health Canada,Ottawa (Canada), A. Golshani - Carleton University,Ottawa (Canada)

Pages

346 - 347

DOI

10.5162/eurosensors2026/Mo-BBS-06

ISBN

978-3-910600-12-6

Price

free

Abstract

This project aims to identify neurotoxic exposure to organophosphate compounds by developing peptides that bind to acetylcholinesterase (AChE). Peptides were generated using the In-Silico Protein Synthesizer (InSiPS) platform to bind human acetylcholinesterase. Peptide interaction with native and inhibited enzyme structures was modeled using molecular docking to predict interaction affinities and binding confirmations. The best peptides demonstrated confirmation-dependent interaction patterns, which will be used for laboratory validation and future field-deployable chemical detection applications.