B3.4 Synthesis of MIP Nanoparticles for Selective Sensing of Penicillin V
- SMSI 2020
(did not take place because of Covid-19 virus pandemic)
- SMSI 2020 - Sensors and Instrumentation
- B3 Biosensors and Sensors for Biology
- M. Bagheri, P. Lieberzeit - University of Vienna, Vienna (Austria)
- 115 - 116
Molecularly imprinted polymers (MIP) based on an acrylic system have proven useful for sensing Penicillin V in aqueous solvents by the means of quartz crystal microbalances (QCM). Herein we carry that concept further by synthesizing MIP nanoparticles as sensitive matrices. This preliminary study discusses the effects of different parameters, namely solvent type and cross-linker amount, on the morphology of nanoparticles, i.e. particle size, polymer agglomeration and porosity. Overall, this resulted in particles with 300 nm diameter synthesized with trimethylolpropane trimethacrylate (TRIM) in both acetonitrile and methanol. The results indicate narrower size distribution in acetonitrile.