P1BS.3 - Modification of Optical Interferometers with Functional Polymers and Hydrogels for Sensing of Protein Biomarkers

Event
17th International Meeting on Chemical Sensors - IMCS 2018
2018-07-15 - 2018-07-19
Vienna, Austria
Chapter
P-1 - Biosensors
Author(s)
S. Kurzhals, E. Melnik, F. Strasser, P. Muellner, R. Heer, R. Hainberger - AlT Austrian Institute of Technology GmbH, Vienna (Austria), G. Koppitsch - ams AG,Premstätten (Austria)
Pages
479 - 480
DOI
10.5162/IMCS2018/P1BS.3
ISBN
978-3-9816876-9-9
Price
free

Abstract

Surface modification of Mach-Zehnder interferometers with biotin-modified polyethylenimine (PEl-B) and PEI-B loaded hydrogels can give access to biosensors combining highly binding matrices with low non-specific interactions, useful for protein biosensing. Permeability of hydrogel layers prepared by photocrosslinking depends on used precursors as well as crosslinking conditions. Protein loading capacity is probed for both functionalization strategies showing high initial response for directly modified surfaces and linear response with receptor concentration for sensors modified with receptor loaded hydrogels. Further signal increase can be achieved by combining receptor modified surfaces with receptor loaded hydrogel layers.

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