D5.4 - A CMOS Based Polysilicon Nanowire Biosensor for Monitoring the Cardiovascular Disease Markers in Human Serum
- Event
- AMA Conferences 2015
2015-05-19 - 2015-05-21
Nürnberg, Germany - Band
- Proceedings SENSOR 2015
- Chapter
- D5 - Chemical & Bio Sensors
- Author(s)
- I. Wang, C. Lin, C. Peng - National Taiwan University, Taipei (Taiwan), J. Lee - National Taiwan University Hospital (Taiwan), H. Tsai, H. Liao - National Chip Implementation Center, Hsinchu (Taiwan)
- Pages
- 602 - 605
- DOI
- 10.5162/sensor2015/D5.4
- ISBN
- 978-3-9813484-8-4
- Price
- free
Abstract
This study demonstrates a polysilicon nanowire (poly-Si NW) biosensor platform is suitable for biomolecular analytes detection in human serum. Three biomarkers, such as cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP) and Interleukin 6 (IL-6), for cardiovascular diseases are examined. Compared with conventional examination methods, using polysilicon nanowire biosensor not only reduces the inspection time but also economizes the cost of diagnoses. Moreover, these biosensor platforms are made by a standard complementary metal-oxidesemiconductor (CMOS) process. Based on this technology, the developed devices can be easily integrated with different functional modules, such wireless and microfluidic systems. Therefore, this work presents a good potential of CMOS based biosensor platform to accomplish the need of early diagnosis and point-of-care testing (POCT) system.