A3.1 - Development of a Biosensor Platform Measuring the Electrical Resistance in a Tailor-Made System for Biological Barriers to Assess the Barrier Integrity
- Event
- SMSI 2025
2025-05-06 - 2025-05-08
Nürnberg - Band
- Lectures
- Chapter
- A3 - Bio Medical Aplications
- Author(s)
- V. Vogel, D. Brück, R. Zäh, B. Faupel - University of Applied Sciences, Saarbrücken (Germany), S. Schnur, S. Klär, M. Schneider, M. Hittinger - Saarland University, Saarbrücken (Germany)
- Pages
- 42 - 43
- DOI
- 10.5162/SMSI2025/A3.1
- ISBN
- 978-3-910600-06-5
- Price
- free
Abstract
Monitoring the electrical resistance across biological barriers can serve as an indicator of barrier integ-rity. Our biosensor system offers an alternative for electrical resistance measurements in a tailor-made system for biological barriers. Measurements of agarose gels at different concentrations (0.5%, 2% w/v) and volumes (150, 300 μl) should demonstrate the ability to distinguish between different conduc-tive barriers. Resistance differences of intact and perforated barriers should highlight the sensor´s potential to assess the barrier integrity and its application in pharmaceutical research.