A3.1 - Development of a Biosensor Platform Measuring the Electrical Resistance in a Tailor-Made System for Biological Barriers to Assess the Barrier Integrity

Event
SMSI 2025
2025-05-06 - 2025-05-08
Nürnberg
Band
Lectures
Chapter
A3 - Bio Medical Aplications
Author(s)
V. Vogel, D. Brück, R. Zäh, B. Faupel - University of Applied Sciences, Saarbrücken (Germany), S. Schnur, S. Klär, M. Schneider, M. Hittinger - Saarland University, Saarbrücken (Germany)
Pages
42 - 43
DOI
10.5162/SMSI2025/A3.1
ISBN
978-3-910600-06-5
Price
free

Abstract

Monitoring the electrical resistance across biological barriers can serve as an indicator of barrier integ-rity. Our biosensor system offers an alternative for electrical resistance measurements in a tailor-made system for biological barriers. Measurements of agarose gels at different concentrations (0.5%, 2% w/v) and volumes (150, 300 μl) should demonstrate the ability to distinguish between different conduc-tive barriers. Resistance differences of intact and perforated barriers should highlight the sensor´s potential to assess the barrier integrity and its application in pharmaceutical research.

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